(015) Vulvar Lichen Sclerosus is Associated with New Diagnoses of Mood Disorders

Abstract Introduction Vulvar lichen sclerosus (VLS) often presents with chronic pruritus. While VLS is associated feelings of isolation, risk mood disorders among females has yet to be quantified on a large scale. Objective Our objective was assess the association development depressive episode, anxiety disorder, major disorder (MDD), and prescription antidepressants benzodiazepines, evaluate impact treatment. Methods A US claims database network (TriNetX Diamond Network) queried from 2009 2022. Cohorts included women aged ≥18 (LS) (ICD-10: L90.0) without prior diagnosis MDD (F33), episode (F32), or (F40-F48) previously prescribed (VA: CN600) benzodiazepines (CN302). We compared control cohort LS sparing vulva affecting (N90.4). conducted sub-analysis by age (18-40, 41-55, >55 years). who received treatment (topical steroids (DE200), vaginal estrogen (GU500), prednisone (8640), hydroxyzine (5553), amitriptyline (704), gabapentin (25480), tacrolimus (42316)) did not receive within 6 months diagnosis. Finally, we receiving only topical steroids, estrogen, tacrolimus) those no Outcomes interest were episodes, Propensity score matching performed for age, ethnicity, race, type 1 diabetes (E10), vitiligo (L80), autoimmune thyroiditis (E06.3), alopecia areata (L63), pernicious anemia (D51.0), overweight obesity (E66), 2 (E11), hyperlipidemia (E78), essential hypertension (I10), alcohol abuse (F10.10). Results 124,237 patients had 16,676 VLS. increased (risk ratio (RR) [95% Confidence Interval] 1.62 [1.32-1.99]), (RR 1.82 [1.50-2.22]), 2.61 [1.69-4.03]) (Table 1) vulva. Women also more likely 1.91 [1.60-2.29]) 1.70 [1.44-2.01]). Among menopausal women, 2.00 [1.10-3.63]) 2). postmenopausal 1.73 [1.38-2.17]), 2.60 [1.64-4.12]), 1.58 [1.29-1.94]), 1.55 [1.30-1.86]), 1.48 [1.24-1.76]). VLS, decreased 0.68 [0.47-0.98]) [1.54-2.59]) [1.31-2.20]) 3). Stratifying type, treated solely topicals numerically, but significantly, lower developing 0.73 [0.48-1.11]) Conclusions demonstrate that vulva, have an antidepressant benzodiazepine prescriptions MDD. Patients should screened these conditions, considered. Disclosure No